Cov epidermis qhuav txhais tau tias daim tawv nqaij thaiv tsis zoo, cov lipids ploj mus, cov protein txo qis.

Tom qab muaj kev puas tsuaj loj heev lossis ntev rau daim tawv nqaij, lub tshuab kho kom zoo ntawm daim tawv nqaij yuav ua kom cov keratinocytes tsim tau sai dua, ua kom lub sijhawm hloov pauv ntawm cov hlwb epidermal luv dua, thiab ua rau muaj cov cytokines thiab tso tawm, ua rau muaj hyperkeratosis thiab o ntawm daim tawv nqaij. Qhov no kuj yog ib qho tshwm sim ntawm cov tsos mob ntawm daim tawv nqaij qhuav.

Kev mob hauv zos kuj tseem tuaj yeem ua rau daim tawv nqaij qhuav zuj zus, qhov tseeb, qhov kev tawg ntawm cov epidermal barrier txhawb kev tsim thiab tso tawm ntawm cov cytokines pro-inflammatory, xws li IL-1he TNF, yog li ntawd cov hlwb tiv thaiv kab mob phagocytic, tshwj xeeb tshaj yog neutrophils, raug rhuav tshem. Tom qab raug nyiam rau qhov chaw qhuav, tom qab mus txog qhov chaw, neutrophils tso tawm leukocyte elastase, cathepsin G, protease 3, thiab collagenase rau hauv cov ntaub so ntswg ib puag ncig, thiab tsim thiab nplua nuj protease hauv keratinocytes. Cov txiaj ntsig ntawm kev ua haujlwm protease ntau dhau: 1. Kev puas tsuaj ntawm tes; 2. Kev tso tawm ntawm cov cytokines pro-inflammatory; 3. Kev puas tsuaj ua ntej ntawm cov tes-rau-tes sib cuag uas txhawb nqa cell mitosis. Kev ua haujlwm proteolytic enzyme hauv daim tawv nqaij qhuav, uas kuj tseem yuav cuam tshuam rau cov hlab ntsha sensory hauv epidermis, yog txuam nrog pruritus thiab mob. Kev siv tshuaj tranexamic acid thiab α1-antitrypsin (ib qho protease inhibitor) rau xerosis yog qhov zoo, qhia tias xeroderma yog txuam nrog kev ua haujlwm proteolytic enzyme.

Cov epidermis qhuav txhais tau tiasdaim tawv nqaij thaiv raug cuam tshuam, cov lipids ploj mus, cov protein raug txo qis, thiab cov tshuaj o hauv zos raug tso tawm.Daim tawv nqaij qhuav los ntawm kev puas tsuaj ntawm cov khoom thaivtxawv ntawm qhov qhuav los ntawm kev txo cov sebum secretion, thiab cov nyhuv ntawm cov lipid ntxiv yooj yim feem ntau tsis ua raws li qhov xav tau. Cov tshuaj pleev ib ce moisturizing tsim rau kev puas tsuaj ntawm barrier yuav tsum tsis txhob tsuas yog ntxiv stratum corneum moisturizing yam, xws li ceramides, cov yam ntuj moisturizing yam, thiab lwm yam, tab sis kuj xav txog cov teebmeem ntawm antioxidant, anti-inflammatory, thiab anti-cell division, yog li txo qhov tsis tiav ntawm keratinocytes. Barrier daim tawv nqaij qhuav feem ntau nrog los ntawm pruritus, thiab ntxiv cov antipruritic actives yuav tsum tau xav txog.