Tshuaj pleev ib ce dawb thiabPigmentMetabolism
Melanin anabolism muab faib ua ntau lub sijhawm. Cov kws tshawb fawb ntseeg tias nws muaj peev xwm kawm cov tshuaj ntxuav hniav dawb thiab ua haujlwm rau lub sijhawm sib txawv ntawm cov metabolism.
(1) Thaum ntxov theem ntawm melanin synthesis
① cuam tshuam nrog kev sau thiab / lossis glycosylation ntawm tyrosinase; ② inhibit regulators nyob rau hauv tsim ntawm tyrosinase; ③ Kev tswj xyuas tom qab kev hloov pauv ntawm tyrosinase.
(2) Lub sijhawm melanin synthesis
Raws li qhov tseem ceeb enzyme thiab tus nqi-txheej enzyme rau melanin synthesis, tyrosinase inhibitors yog lub ntsiab kev tshawb fawb thiab kev loj hlob kev taw qhia tam sim no. Txij li feem ntau cov tshuaj ntxuav hniav dawb xws li phenol thiab catechol derivatives yog cov qauv zoo ib yam li tyrosine thiab dopa, cov tshuaj ntxuav hniav dawb uas tau tshuaj ntsuam xyuas feem ntau yog cov tsis muaj kev sib tw lossis kev sib tw inhibitors ntawm tyrosinase.
(3) Lub sijhawm kawg ntawm melanin synthesis
① inhibits melanosome hloov; Cov tshuaj nrog serine protease inhibitory nyhuv, xws li rwj-50353, kom tsis txhob UBV-induced epidermal pigmentation; soybean trypsin inhibitor muaj cov nyhuv whitening tab sis tsis muaj kev cuam tshuam rau cov tshuaj lom ntawm cov xim xim; Niacinamide, tuaj yeem cuam tshuam kev sib kis ntawm melanocytes ntawm melanocytes thiab keratinocytes; ② Melanin dispersion thiab metabolism, α-hydroxy acid, dawb fatty acid thiab retinoic acid, txhawb lub cell txuas ntxiv thiab txhawb melaninized keratinocytes ntawm kev tshem tawm.
Nws yog ib qho tsim nyog sau cia tias kev tshawb fawb thiab kev siv tshuaj ntxuav hniav dawb raws li cov metabolism hauv melanin saum toj no tsis haum rau kev tiv thaiv thiab kev kho mob ntawm cov plaques senile. Txij li thaum lub mechanism ntawm senile plaque tsim muaj feem xyuam rau qhov tsim ntawm lipofuscin, antioxidative active tshuaj feem ntau yog siv los ncua thiab thim rov qab senile plaques.
Post lub sij hawm: Lub Xya hli ntuj-29-2022
