Tshuaj pleev ib ce kom dawb thiabXim avKev ua haujlwm ntawm lub cev
Kev tsim cov melanin hauv lub cev muaj ntau lub sijhawm sib txawv. Cov kws tshawb fawb ntseeg tias nws yog qhov ua tau los kawm txog cov tshuaj dawb thiab ua haujlwm rau ntau lub sijhawm sib txawv.
(1) Theem thaum ntxov ntawm melanin synthesis
① Cuam tshuam rau kev sau ntawv thiab/lossis glycosylation ntawm tyrosinase; ② Tiv thaiv cov neeg tswj hwm hauv kev tsim tyrosinase; ③ Kev tswj hwm tom qab kev sau ntawv ntawm tyrosinase.
(2) Lub sijhawm tsim cov melanin
Raws li qhov tseem ceeb enzyme thiab tus nqi-limiting enzyme rau melanin synthesis, tyrosinase inhibitors yog lub ntsiab kev tshawb fawb thiab kev loj hlob kev taw qhia tam sim no. Vim tias feem ntau cov neeg sawv cev dawb xws li phenol thiab catechol derivatives yog cov qauv zoo sib xws rau tyrosine thiab dopa, cov neeg sawv cev dawb uas tau kuaj xyuas feem ntau yog cais ua cov tsis sib tw lossis sib tw inhibitors ntawm tyrosinase.
(3) Theem lig ntawm kev tsim melanin
①Inhibits melanosome hloov; cov tshuaj nrog serine protease inhibitory nyhuv, xws li rwj-50353, kiag li zam UBV-induced epidermal pigmentation; soybean trypsin inhibitor muaj cov nyhuv whitening pom tseeb tab sis tsis muaj kev cuam tshuam rau qhov lom ntawm cov hlwb pigment; Niacinamide, tuaj yeem cuam tshuam kev sib kis ntawm melanocytes ntawm melanocytes thiab keratinocytes; ② Melanin dispersion thiab metabolism, α-hydroxy acid, free fatty acid thiab retinoic acid, txhawb kev tsim kho tshiab ntawm tes thiab txhawb nqa melaninized keratinocytes ntawm kev tshem tawm.
Nws yog ib qho tsim nyog sau tseg tias kev tshawb fawb thiab kev siv cov tshuaj dawb raws li cov metabolism melanin saum toj no tsis haum rau kev tiv thaiv thiab kho cov senile plaques. Txij li thaum lub tshuab ntawm senile plaque tsim yog cuam tshuam nrog kev tsim ntawm lipofuscin, cov tshuaj antioxidant nquag feem ntau siv los ncua thiab thim rov qab senile plaques.
Lub sijhawm tshaj tawm: Lub Xya Hli-29-2022
